Lipid droplets are cytoplasmic organelles that store neutral lipids (e.g. triacylglycerols & sterol esters) that serve as reservoirs of energy. The neutral lipid core of lipid droplets are bounded by a phospholipid monolayer, which differentiates them from most other organelles that have a bilayer membrane. There are various nano-environments of …
We are excited that our recent paper in which we reported the results of a multi-disciplinary investigation of the antimicrobial activity of protein pseudocapsids (ACS Nano (2020) 14, 1609-1622) has been garnering a lot of attention within the media and the scientific community since its publication. This paper contained simulation …
Surfactant-covered aqueous interfaces are ubiquitous in everyday life. These interfaces play a key role in various commercial products, where surfactants adsorb onto the surface of bubbles or oil droplets to stabilize foams and emulsions. Examples of such foams and emulsions are commonly found in pharmaceuticals, detergents, cosmetics and lubricants. In …
Our recent manuscript — “Minor chemistry changes alter surface hydration to control fibronectin adsorption and assembly into nanofibrils” — reports the results of a multi-disciplinary investigation of mechanisms that govern material-driven fibrillogenesis. Previously, our collaborators in Prof. Manuel Salmeron-Sanchez‘s group at the University of Glasgow showed that fibronectin formed fibril …
In our recent manuscript entitled “On the structure of solid lipid nanoparticles“, we have combined large-scale all-atom molecular dynamics simulations and small angle neutron scattering (SANS) experiments to provide the first detailed description of the internal structure and atomistic interactions which govern this structure of liquid and solid lipid aggregates, …
Our latest manuscript entitled “Molecular insights into the behaviour of bile salts at interfaces: a key to their role in lipid digestion” features work that we have done in collaboration with the groups of Cécile Dreiss (Institute of Pharmaceutical Science, KCL), Richard Harvey (Institut für Pharmazie, Martin Luther Universität Halle-Wittenberg), …
Our latest manuscript entitled “On the interaction of hyaluronic acid with synovial fluid lipid membranes” features work by two PhD students in the lab (Paul Smith & Rob Ziolek) and an undergraduate student who worked with us last summer (Elena Gazzarrini). In this manuscript, we used all-atom molecular dynamics simulations to …
We have recently published a manuscript entitled “On the hydration of DOPE in solution” in collaboration with Sylvia McLain’s group at the University of Oxford. In this manuscript, we utilise neutron diffraction and NMR experiments alongside Empirical Potential Structure Refinement (EPSR) and atomistic molecular dynamics simulations to gain a state-of-the-art …