The effect that solvents and co-solvents have on the structural and dynamic properties of lipid molecules in self-assembled structures is of significant interest for a variety of applications ranging from drug delivery and personal care formulations to cryopreservation. In this manuscript, we elucidate the underlying molecular scale mechanisms which lead …
In this work, we elucidate the underlying molecular scale mechanisms which drive the encapsulation of two different small molecule drugs within Triton X-100 surfactant micelles, and how the encapsulation effects the structural properties of the micelles. Specifically, we have investigated the encapsulation of two different nonsteroidal anti-inflammatory drugs (NSAIDs), ibuprofen …
We have recently published a manuscript entitled “On the hydration of DOPE in solution” in collaboration with Sylvia McLain’s group at the University of Oxford. In this manuscript, we utilise neutron diffraction and NMR experiments alongside Empirical Potential Structure Refinement (EPSR) and atomistic molecular dynamics simulations to gain a state-of-the-art …