The effect that solvents and co-solvents have on the structural and dynamic properties of lipid molecules in self-assembled structures is of significant interest for a variety of applications ranging from drug delivery and personal care formulations to cryopreservation. In this manuscript, we elucidate the underlying molecular scale mechanisms which lead …
In this manuscript, we identify the underlying molecular scale mechanisms that drive the solubilisation of two different small molecule drugs within Triton X-114 surfactant micelles, and how the solubilisation affects the structural properties of the micelles. Specifically, we have investigated the solubilisation of the sodium salts of two different nonsteroidal …
In this work, we elucidate the underlying molecular scale mechanisms which drive the encapsulation of two different small molecule drugs within Triton X-100 surfactant micelles, and how the encapsulation effects the structural properties of the micelles. Specifically, we have investigated the encapsulation of two different nonsteroidal anti-inflammatory drugs (NSAIDs), ibuprofen …
In our recent manuscript we elucidate vital information into how the interactions between a surfactant and a lipid effect the internal structure and morphology of the nanoparticles that they form. In doing so, we implement machine learning techniques alongside small angle neutron scattering experiments and molecular dynamics simulations to provide …
In this manuscript, we elucidate the underlying molecular scale mechanisms which drive the changes in the dynamic and structural properties of phosphatidylcholine micelles as they are digested by the phospholipase A2 (PLA2) enzyme. Specifically, we have investigated micelles consisting of dihexanoylphosphatidylcholine (2C6PC) which have potential as drug delivery vehicles for …
Biomimetic liquid crystalline systems are widely used in skin care cosmetics and topical pharmaceutical preparations. Multi-component lipid/surfactant formulations that contain natural phospholipids combined with long chain fatty acids and alcohols are widely employed in so-called ‘biomimetic’ skin care preparations. Such products – which include, for example, the PhysiogelTM and BiophilicTM …
Congratulations to Demi Pink for being awarded the inaugural Jacky Pallas Memorial Award. This award is memory of Jacky Pallas, who passed away suddenly and unexpectedly earlier this year. Jacky was someone that I had the pleasure to interact with on several occasions in her role as head of e-Research …
In our recent manuscript entitled “On the structure of solid lipid nanoparticles“, we have combined large-scale all-atom molecular dynamics simulations and small angle neutron scattering (SANS) experiments to provide the first detailed description of the internal structure and atomistic interactions which govern this structure of liquid and solid lipid aggregates, …