In this manuscript, we elucidate the underlying molecular scale mechanisms which drive the changes in the dynamic and structural properties of phosphatidylcholine micelles as they are digested by the phospholipase A2 (PLA2) enzyme. Specifically, we have investigated micelles consisting of dihexanoylphosphatidylcholine (2C6PC) which have potential as drug delivery vehicles for …
Bile salts (BS) are biosurfactants released into the small intestine, which play key and contrasting roles in lipid digestion: they adsorb at interfaces and promote the adsorption of digestive enzymes onto fat droplets, while they also remove lipolysis products from that interface, solubilising them into mixed micelles. Small architectural variations …
Our latest manuscript entitled “Molecular insights into the behaviour of bile salts at interfaces: a key to their role in lipid digestion” features work that we have done in collaboration with the groups of Cécile Dreiss (Institute of Pharmaceutical Science, KCL), Richard Harvey (Institut für Pharmazie, Martin Luther Universität Halle-Wittenberg), …