Cholesterol plays a key role in the molecular and mesoscopic organisation of lipid membranes and it is expected that changes in its molecular structure (e.g., through environmental factors such as oxidative stress) may affect adversely membrane properties and function. In this study, we present evidence that oxidation of cholesterol has …
The effect that solvents and co-solvents have on the structural and dynamic properties of lipid molecules in self-assembled structures is of significant interest for a variety of applications ranging from drug delivery and personal care formulations to cryopreservation. In this manuscript, we elucidate the underlying molecular scale mechanisms which lead …
Our latest manuscript entitled “Molecular insights into the behaviour of bile salts at interfaces: a key to their role in lipid digestion” features work that we have done in collaboration with the groups of Cécile Dreiss (Institute of Pharmaceutical Science, KCL), Richard Harvey (Institut für Pharmazie, Martin Luther Universität Halle-Wittenberg), …