In our recent manuscript, we provide new fundamental insights into the microscopic structure of linear and four-arm block copolymers (members of the Pluronic and Tetronic families, respectively). The Pluronics and Tetronics typically self-assemble into small micelles in aqueous solution, which have found societally important applications in biomaterials and drug delivery. …
In this work, we elucidate the pH-directed self-assembly of Tetronic 304 (T304), a four-arm block copolymer. T304, as the smallest member of the Tetronics family, acts as an ideal testing ground to probe the underlying mechanisms that determine the self-assembly behaviour of this important class of polymers, which are of …
Bile salts (BS) are biosurfactants released into the small intestine, which play key and contrasting roles in lipid digestion: they adsorb at interfaces and promote the adsorption of digestive enzymes onto fat droplets, while they also remove lipolysis products from that interface, solubilising them into mixed micelles. Small architectural variations …
Our latest manuscript entitled “Molecular insights into the behaviour of bile salts at interfaces: a key to their role in lipid digestion” features work that we have done in collaboration with the groups of Cécile Dreiss (Institute of Pharmaceutical Science, KCL), Richard Harvey (Institut für Pharmazie, Martin Luther Universität Halle-Wittenberg), …