New Paper: “Morphology of bile salts micelles and mixed micelles with lipolysis products, from scattering techniques and atomistic simulations”

Bile salts (BS) are biosurfactants released into the small intestine, which play key and contrasting roles in lipid digestion: they adsorb at interfaces and promote the adsorption of digestive enzymes onto fat droplets, while they also remove lipolysis products from that interface, solubilising them into mixed micelles. Small architectural variations …

New Paper: “Two coexisting membrane structures are defined by lateral and transbilayer interactions between sphingomyelin and cholesterol”

Sphingomyelin and cholesterol are prominent lipids in the plasma membrane of animal cells.  In this manuscript, we have combined X-ray scattering experiments, performed by our collarborator Prof. Peter Quinn (KCL, Institute of Pharmaceutical Science), and all-atom molecular dynamics to investigate the bilayer structures observed within an equimolar mixture of palmitoylsphingomyelin …