Phospholipids are a diverse group of biomolecules consisting of a hydrophilic headgroup and two hydrophobic acyl tails. The nature of the head and length and saturation of the acyl tails are important for defining the biophysical properties of lipid bilayers. It has recently been shown that the membranes of certain yeast …
In our latest manuscript, we elucidate the atomistic mechanisms that define the interactions between two commonly used environmentally sensitive dyes (Laurdan & di-4-ANEPPDHQ) and liquid-ordered (Lo) and liquid-disordered (Ld) lipid bilayers which they are used to investigate. Laurdan and di-4-ANEPPDHQ are solvatochromatic dyes that are perfect for probing lipid phases …
Our latest manuscript entitled “On the interaction of hyaluronic acid with synovial fluid lipid membranes” features work by two PhD students in the lab (Paul Smith & Rob Ziolek) and an undergraduate student who worked with us last summer (Elena Gazzarrini). In this manuscript, we used all-atom molecular dynamics simulations to …