New Paper: “Temporin B forms hetero-oligomers with temporin L, modifies its membrane activity, and increases the cooperativity of Its antibacterial pharmacodynamic profile”

In our most recent paper in collaboration with James Mason, David Phoenix & J. Mark Sutton, we have carried out a multi-disciplinary investigation of the synergistic effects of the antimicrobial peptides, temporin B & temporin L. The temporins comprise a very well-studied family of AMPs that now number more than …

New Paper: “Nanocapsule designs for antimicrobial resistance”

The pressing need of new antimicrobial products is growing stronger, particularly because of widespread antimicrobial resistance, endangering our ability to treat common infections. The recent coronavirus pandemic has dramatically highlighted the necessity of effective antibacterial and antiviral protection. This work explores at the molecular level the mechanism of action of …

New Paper: “A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy”

The 2016 Review on Antimicrobial Resistance (AMR) predicts that, unless action is taken, around 10 million deaths per year will be attributable to AMR by the year 2050. The pipeline of new antibiotics is limited, hence the potential of numerous alternatives to antibiotics – “noncompound approaches (i.e. products other than …

Irene Marzuoli successfully defended her PhD thesis

On 31 January, Irene Marzuoli, who was co-supervised by Prof. Franca Fraternali in the Randall Centre for Cell & Molecular Biology, was examined by Prof. Syma Khalid (University of Southampton) and Prof. Fernando Bresme (Imperial College London) during her PhD viva.  Irene’s viva was during the afternoon, and in the end the examiners …

Our paper on antimicrobial pseudocapsids is garnering a lot of attention

We are excited that our recent paper in which we reported the results of a multi-disciplinary investigation of the antimicrobial activity of protein pseudocapsids (ACS Nano (2020) 14, 1609-1622) has been garnering a lot of attention within the media and the scientific community since its publication.  This paper contained simulation …

Welcome to Raquel Lopez-Rios De Castro!

Raquel Lopez-Rios De Castro, who has just completed her BSc in Physics at King’s College London, has been awarded one of the eleven summer bursaries that have been awarded for the Summer of 2019 by the EPSRC/BBSRC funded Physics of Life network 2 (details of call here). Raquel will be …