Our paper on antimicrobial pseudocapsids is garnering a lot of attention

We are excited that our recent paper in which we reported the results of a multi-disciplinary investigation of the antimicrobial activity of protein pseudocapsids (ACS Nano (2020) 14, 1609-1622) has been garnering a lot of attention within the media and the scientific community since its publication.  This paper contained simulation work, which was carried out by Irene Marzuoli in collaboration with Prof. Franca Fraternali in the Randall Centre for Cell & Molecular Biophysics, that provided (a) a detailed description of the molecular scale interactions which are key to the formation and stabilisation of the antimicrobial peptide pseudocapsids, (b) an understanding of what the general structure of the molecules within the pseudocapsid (they are formed by a bilayer of peptides not a monolayer) and (c) a detailed description of the mechanism of action of these pseudocapsids when interacting with model bacterial membranes. All of which provide a perfect compliment to the beautiful experimental work done in the groups of Dr. Max Ryadnov (National Physical Laboratory) and Prof. Bart Hoogenboom (UCL).  This work has recently been the subject of articles published by The Times, The Daily Mail, The Express, and the KCL News Centre.  Additionally, Dr. Frank Sainsbury (Griffith University) wrote a perspective in ACS Nano on the paper, and the paper was recognised with cover artwork on the corresponding issue of ACS Nano.

 

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