New paper: “Allosteric Regulation of SARS-CoV-2 Protease: Towards Informed Structure-Based Drug Discovery”
The SARS-CoV-2 main protease is a target for the development of novel therapeutics for COVID-19. Based on crystal structure data from the homologous SARS-CoV-1 protease, the binding site would be expected to adopt two possible conformations – a close-apo-like structure with the His-Cys catalytic dyad intact, and an open structure …