Tag: COVID-19

Grants

Awarded a UKRI grant to develop a coronavirus sensor

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Our project, entitled ‘DisCoVer: Aptamer biosensors for the detection of SARS-CoV-2 on surfaces’, is a collaboration between Dr Nunzianda Frascione and Dr James Gooch from the School of Population Health & Environmental Sciences and Professor Mark Green  from the Department of Physics.  Rob Ziolek is going to continue on working in the group as …

Papers

New paper: “Allosteric Regulation of SARS-CoV-2 Protease: Towards Informed Structure-Based Drug Discovery”

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The SARS-CoV-2 main protease is a target for the development of novel therapeutics for COVID-19.  Based on crystal structure data from the homologous SARS-CoV-1 protease, the binding site would be expected to adopt two possible conformations – a close-apo-like structure with the His-Cys catalytic dyad intact, and an open structure …