by Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Abstract:
The International Mouse Phenotyping Consortium (IMPC) web portal (http://www.mousephenotype.org) provides the biomedical community with a unified point of access to mutant mice and rich collection of related emerging and existing mouse phenotype data. IMPC mouse clinics worldwide follow rigorous highly structured and standardized protocols for the experimentation, collection and dissemination of data. Dedicated ‘data wranglers’ work with each phenotyping center to collate data and perform quality control of data. An automated statistical analysis pipeline has been developed to identify knockout strains with a significant change in the phenotype parameters. Annotation with biomedical ontologies allows biologists and clinicians to easily find mouse strains with phenotypic traits relevant to their research. Data integration with other resources will provide insights into mammalian gene function and human disease. As phenotype data become available for every gene in the mouse, the IMPC web portal will become an invaluable tool for researchers studying the genetic contributions of genes to human diseases.
Reference:
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data (Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson), In Nucleic Acids Research, volume 42, 2014.
Bibtex Entry:
@Article{Koscielny2014,
author = {Koscielny, Gautier and Yaikhom, Gagarine and Iyer, Vivek and Meehan, Terrence F. and Morgan, Hugh and Atienza-Herrero, Julian and Blake, Andrew and Chen, Chao-Kung and Easty, Richard and Di Fenza, Armida and Fiegel, Tanja and Grifiths, Mark and Horne, Alan and Karp, Natasha A. and Kurbatova, Natalja and Mason, Jeremy C. and Matthews, Peter and Oakley, Darren J. and Qazi, Asfand and Regnart, Jack and Retha, Ahmad and Santos, Luis A. and Sneddon, Duncan J. and Warren, Jonathan and Westerberg, Henrik and Wilson, Robert J. and Melvin, David G. and Smedley, Damian and Brown, Steve D. M. and Flicek, Paul and Skarnes, William C. and Mallon, Ann-Marie and Parkinson, Helen},
title = {The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data},
volume = {42},
number = {D1},
pages = {D802-D809},
year = {2014},
doi = {10.1093/nar/gkt977},
abstract ={The International Mouse Phenotyping Consortium (IMPC) web portal (http://www.mousephenotype.org) provides the biomedical community with a unified point of access to mutant mice and rich collection of related emerging and existing mouse phenotype data. IMPC mouse clinics worldwide follow rigorous highly structured and standardized protocols for the experimentation, collection and dissemination of data. Dedicated ‘data wranglers’ work with each phenotyping center to collate data and perform quality control of data. An automated statistical analysis pipeline has been developed to identify knockout strains with a significant change in the phenotype parameters. Annotation with biomedical ontologies allows biologists and clinicians to easily find mouse strains with phenotypic traits relevant to their research. Data integration with other resources will provide insights into mammalian gene function and human disease. As phenotype data become available for every gene in the mouse, the IMPC web portal will become an invaluable tool for researchers studying the genetic contributions of genes to human diseases.},
URL = {http://nar.oxfordjournals.org/content/42/D1/D802.abstract},
eprint = {http://nar.oxfordjournals.org/content/42/D1/D802.full.pdf+html},
journal = {Nucleic Acids Research}
}